What is MyoStim ED Erectistim and Erectistim Plus?
What is MyoStim ED's ErectiStim Plus Lite TM product?
ErectiStim Plus Lite TM is a simpler fewer component and less costly version of ErectiStim Plus TM which is available on the USA market now for use at qualified research centers.
ErectiStim Plus Lite TM has these 3 base components…
1. ErectiStim TM bioelectric stimulation of SDF1, PDGF, VEGF, klotho, follistatin, sonic hedgehog
2. Platelet Rich Fibrin (PRF) which is produced bedside in minutes with a special BIO PRF centrifuge from a small blood sample from the patient – see BIO PRF science 1) https://bio-prf.com/science-behind-bio-prf/ and to order (2) https://bio-prf.com/shop-page/ + (3) patent pending https://patents.justia.com/patent/20200000709. May include bioelectrically treated pre-injection PRF and bioelectrically stimulated post injected PRF as well to unlock more regenerative proteins and to extend, amplify and enhance the release of existing PRF regenerative proteins – see (4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388803/
3. Regenerative fluid from amniotic sourcing from Axolotl Biologix – https://azbigmedia.com/business/bioscience-industry/phoenix-based-axolotl-biologix-partners-with-leonhardt-ventures/
and in qualified research centers may also include as special booster additives…
5. Immature myoblasts (muscle stem cells) – see paper published by Dr. Nestor Gonzalez-Cadavid our Chief Scientific Advisor at MyoStim ED > (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886867/
6. Adipose tissue derived stem cells, stromal fraction and endothelial progenitor cells – see ordering information for processing devices (1) https://www.tissuegenesis.com/icellator-x/ or (2) https://www.synovalife.com + supporting published papers (3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678927/ + (4) 12 month followup https://www.ncbi.nlm.nih.gov/pubmed/29958973
7. Wharton’s Jelly – https://stemcellstransplantinstitute.com/2019/10/03/properties-whartons-jelly-mesenchymal-stem-cells/ + https://www.centerwatch.com/clinical-trials/listings/186921/erectile-dysfunction-use-wharton-jelly-erectile/
Recommended ErectiStim Plus Lite TM Treatment Protocol
2. 2mls of PRF mixed with either regenerative fluid derived from amniotic sourcing, and/or Wharton’s Jelly and/or selected exosomes 1X a month for 3 months and touch ups 1X injection session every 2 years.
Additive booster protocol…
3. Autologous myoblast (muscle stem cells) derived from patient’s own thigh muscle – 1X a month for 3 months mixed with PRF and regenerative fluid for 3 months and touch ups 1X injection sessions every 2 years.
4. Adipose tissued derived stromal fraction, stem cells and endothelial progenitor cells mixed with PRF and regenerative fluid delivery 1X a month for 3 months and touch ups 1X injection sessions every 2 years.
PRF gel is essential to reduce migration of fluids away from intended treatment location.
Biologics are delivered via careful slow infusion hand 5 minute injection into the penis corpora cavernosa via a simple standard hypodermic 2ml or two 1ml syringes and via a standard 26 or 27 gauge needle attached to tip. The penis and patient should be immobilized during this slow infusion session to avoid injury.
Note – Total volume of biologics composition is 2ml per injection session max of 1 per month for 3 consecutive months whether just PRF and amnio fluid or including booster additives of selected exosomes, Wharton’s Jelly, adipose derived stromal fraction and cells and/or immature myoblasts (muscle stem cells).
How are Erectistim and Erectistim Plus intended to work?
ErectiStim employs precise bioelectric signaling sequences directly into the penis non-invasively. The precise signaling sequences control release of specific regenerative proteins on demand such as SDF1 for stem cell homing, IGF1 and EGF for DNA repair and nerve regeneration, Follistatin and Klotho for muscle regeneration, VEGF, PDGF, HIF1a, CXCL5, HGF, EGF, SDF1 and eNOS for not only improving blood circulation but actually creating new large inner diameter mature (true endothelium lining) blood vessels. There are signaling sequences designed to address the neuromodulation component of ED. So in summary Erecstim is designed to (1) improve blood flow not just temporarily but long term, (2) regenerate penile muscle tissue and bring into balance the myostatin vs follistatin ratio, (3) regenerative nerve tissue, (4) help recover healthy normal neuro hormonal function related to ED. The center of the ErectiStim IP platform is bioelectric signaling sequences via SDF1 and PDGF for (1) stem cell homing, (2) muscle regeneration via follistatin and klotho, (3) regenerate nerve tissue. (4) new mature blood vessel formation via VEGF, PDGF, EGF, HGF, SDF1, HIF1a, CXCL5 and eNOS, (5) neuro hormonal balancing via bioelectric signaling simulating normal environmental stimuli. Note – In early studies we are to utilizing our full line up of bioelectric signaling sequences. The first study was with just the single VEGF signal alone for blood flow improvement. The 2nd study includes some of the bioelectric signaling sequences for mature lasting large diameter new blood vessel formation, muscle regeneration and nerve regeneration but not all of them.
What are the intended benefits of MyoStim Erectistim and ErectiStim Plus?
Warning cautionary statement – these listing POTENTIAL benefits are not clearly proven out yet in statistically significant placebo controlled Phase II/III studies under IRB and regulatory body supervision. Only one small pilot study has been completed to date which is inconclusive in these results.
- Harder erections
- More spontaneous erections
- More sustainable erections
- Enhanced sensation
- Better orgasms
- Increased length and girth
- Improved sexual performance
How long are the effects of Erectistim and Erectistim expected to last?
The effects of Erectistim have only been clinically tested in a limited small series of patients to date in a pilot study with follow-up limited to under 6 months. The product developers intend to prove out in new longer duration follow-up clinical studies to last at least two to three years after the initial treatment and possibly up to 10 years. A maintenance program of scheduled treatments may be needed to help maintain the effects over a longer period of time. Erectistim Plus by design is expected to provide even longer lasting effects than the original Erectistim product but their is not conclusive data to support this claim at this time.
Is Erectistim and Erectistim Plus FDA approved?
Is this technology new?
Is their clinical research to prove Erectistim works?
This study highlighted below was completed just using one single bioelectric signal for 15 minutes 2X a week for only 4 weeks. A new study has started enrollment at the same center this time with 5 bioelectric signaling sequences and will include longer term followupInt J Impot Res. 2018 Jun;30(3):97-101. doi: 10.1038/s41443-018-0024-8. Epub 2018 May 22.
An initial study on the effect of functional electrical stimulation in erectile dysfunction: a randomized controlled trial.
AbstractErectile dysfunction (ED) affects approximately 150 million men worldwide. Functional electrical stimulation (FES) therapy has shown a high regenerative capacity for smooth muscle cells and, therefore, is being increasingly adopted. FES can be a beneficial treatment option when the cause of ED is related to degeneration of cavernous smooth muscle. To evaluate the impact of FES on erectile function in men with erectile dysfunction. Twenty-two patients with ED participated in this randomized clinical trial. Participants were randomly assigned to two groups: intervention (IG) or control (CG). IG participants underwent FES therapy (50 Hz/500 µs) for a total of 4 weeks, divided into two weekly sessions lasting 15 min each, with intensity lower than the motor threshold. CG participants were treated with placebo FES and followed the same routine as the IG. Erectile function was assessed by the validated International Index of Erectile Function (IIEF-5) and Erection Hardness Score (EHS), applied before and after treatment, and quality of life, by the WHOQOL questionnaire. Statistically significant differences in IIEF-5 and EHS were found between the IG and CG after treatment (p < 0.05), as well as a within-group difference in the IG when comparing the post-treatment periods (p < 0.0001) The WHOQOL revealed a significant difference between CG and IG after treatment (p < 0.05), as well as a within-group difference in the IG after treatment (p < 0.0001), except in the Environment domain, in which there was no difference between the pre- and post-treatment periods (50.9 ± 2.8 pre vs. 52.3 ± 3.1 post). This trial showed that FES therapy may improve erectile function and quality of life in men with ED.
How many treatments are required?
What are the potential and intended advantages of MyoStim ED Erectistim over other therapy choices?
Warning caution – any performance or safety claims are yet to be fully proven out in statistically significant placebo controlled Phase II/II studies.
- Is drug and surgery free
- Is completely non-invasive and has no known side-effects reported to date in small pilot studies (inconclusive more studies required)
- Is a simple in-office OR AT HOME procedure with each treatment taking only 15 to 35 minutes.
- Designed and intended to provide long lasting results up to 2 to 3 years and possibly even up to 10 years with no downtime (more studies needed to prove)
- Designed and intended to address multiple root causes of ED – poor blood flow, muscle degeneration, nerve damage and neuro hormonal dysfunction.
- Designed to bring back in balance the myostatin vs follistatin ratio to healthy normal levels. ED patients usually have elevated myostatin levels and depressed Follistatin levels.
- Designed and intended to offer potential long-term improvement rather than a reliance on medications.
Can Erectistim be used in conjunction with other therapies?
Q1 What is the ErectiStim™ by MyoStim ED therapy?
The ErectiStim™ therapy consists of a series of precise bioelectric signals delivered to the penile area or nerves feeding the penis that control various protein expressions for stem cell homing, stem cell proliferation, stem cell differentiation, blood vessel forming and blood circulation improving, muscle function repair and DNA repair. For very severe cases we combine this with a re-fillable micro infusion pump that micro feeds into penile tissue a cocktail of stem cells, growth factors, selected alkaloids, oxygenated nano particles, amniotic fluid, SVF, PRF, nutrient hydrogel and penile matrix in addition to bioelectric stimulation in attempt to stimulate ED recovery.
Q2 What evidence is there that ErectiStim™ by MyoStim ED therapy works?
An initial study on the effect of functional electrical stimulation in …
Establishment of a simple and practical procedure applicable to …
Q3 What protein expressions does the ErectiStim™ by MyoStim ED device control and what do they do?
What is erectile dysfunction (ED)?
Erectile dysfunction (or ED), also called male impotence, is described as a consistent inability to achieve and maintain an erection sufficient for mutually satisfactory sexual intercourse with his partner. By itself, ED is not a disease but more of a signal that something else may be a problem. Erectile dysfunction is a common condition, affecting more than half of men ages 40 to 70.
Sexual dysfunction can sometimes be caused by disorders such as diabetes, high blood pressure, vascular disease, heart disease, nervous system disorders, and depression as well as an unwanted side effect from some medications. Male sexual dysfunction may be the symptom of such disorders that brings them to the doctor’s office in the first place.
Sexual health and function are important in determining a man’s quality of life. As Americans age, disorders such as erectile dysfunction (ED) are becoming increasingly apparent. Because this subject is discussed widely in the media, men and women of all ages are seeking guidance in an effort to improve their relationships and experience satisfying sex lives.
The successful treatment of ED has been shown to improve sexual intimacy and satisfaction, improve sexual aspects of quality of life as well as overall quality of life, and relieve symptoms of depression.
How does a man achieve an erection?
For a man to have an erection, a complex process takes place within his body.
Erection involves the central nervous system, peripheral nervous system, hormones, psychological and stress-related factors, local problems with the penis itself as well as blood flow or circulation. The penile portion of the process leading to erections represents only a single component of a very complex cascade of events.
Erections occur in response to touch, smell, and visual stimuli that trigger pathways in the brain. Information travels from the brain to the nerve centers at the base of the spine, where primary nerve fibers connect to the penis and regulate blood flow during erection and afterward.
Sexual stimulation causes the release of chemicals from the nerve endings in the penis that trigger a series of events that ultimately cause muscle relaxation in the erection bodies of the penis. The smooth muscle in the erection bodies controls the flow of blood into the penis. When the smooth muscle relaxes, the blood flow dramatically increases causing the erection bodies to become full and rigid, resulting in an erection. Venous channels normally draining blood are compressed and close off as the erection bodies enlarge.
Detumescence (when the penis is no longer in a state of erection) results when muscle-relaxing chemicals are no longer released. Ejaculation causes the smooth muscle tissue of the erection bodies in the penis to regain muscle tone, which allows the blood drainage channels to open. As the extra blood drains from the erection bodies, the erection loses rigidity and the penis returns to its original flaccid state.
ED occurs when this process does not progress normally. Arousal and erections are physical and mental activities, so it is important to remember that the sexual partner plays an integral role. Effective management of erection problems and erectile dysfunction is often more successful if the sexual partner is involved with the evaluation and treatment.
Is impotence the same as erectile dysfunction?
Yes, the terms mean the same.
Premature ejaculation is often confused with erectile dysfunction. Premature ejaculation is a condition in which the entire process of arousal, erection, ejaculation, and climax occur very rapidly, often in just a few minutes or even seconds, leaving both the sexual partner and the one experiencing premature ejaculation unsatisfied. Premature ejaculation may accompany an erection problem such as ED but is generally treated differently.
Erection problems will usually produce a significant psychological and emotional reaction in most men. This is often described as a pattern of anxiety and stress that can further interfere with normal sexual function. This “performance anxiety” needs to be recognized and addressed by your doctor.
What causes erectile dysfunction?
Currently, virtually any man who wishes to have an erection can obtain it, regardless of the underlying cause of his problem. Many reasonable treatment options exist. Your first step is to find a well-trained, experienced, and compassionate doctor who is willing to take the time to understand you and fully examine you to discover the cause and discuss the treatments available to you.
Your doctor will want to rule out any other causes for your concern such as high blood pressure, prostate cancer, vascular disease, and diabetes.
By seeing your doctor, you may very well be saving your life if the doctor detects – and treats – a life-threatening illness. Often, you can restore your sexual health by treating a condition such as high blood pressure with diet and exercise or controlling your diabetes.
For some men, erectile dysfunction develops with age or may be related to depression or another psychological cause. In these cases, psychological counseling with you and your sexual partner may be successful.
Medications can cause ED, especially drugs you might take to control blood pressure or depression (antidepressants) (see Impotence/Erectile Dysfunction for a list of medications that may cause ED). Anti-ulcer drugs can be a cause, as can alcohol or drug abuse. ED is a side effect. Talk with your doctor about medications that might not cause this side effect. Do not just stop taking your prescribed medication.
Other causes include damage to the erection bodies in the penis; diabetes; various hormonal disorders; blood flow problems; psychological factors, such as depression; and surgical complications from abdominal, pelvic, or back surgery.
How is erectile dysfunction treated?
Treatment options include sexual counseling, medications, external vacuum devices, hormonal therapy, penile injections, or intraurethral suppositories (see Impotence/Erectile Dysfunction for treatment options). In highly selected cases under the supervision of a urology specialist in ED, combination therapy using several of these methods together can be used. If none of these therapies is satisfactory, penile implants through surgery can be considered.
Most patients start with Viagra and other similar drugs. No one could miss all of the consumer advertising for drugs to aid in ED. You see advertising for these drugs in magazines and on TV. Certainly there are plenty of jokes about Viagra and similar drugs, but ED is not funny if you are experiencing it.
How do drugs like Viagra work?
Viagra (sildenafil citrate), a prescription medication for the treatment of erectile dysfunction, is the first pill available that’s been proven to improve erections in most men with impotence.
Since its introduction in March 1998, no other therapy for ED has achieved such wide public recognition. Viagra doesn’t improve erections in normal men, only in those with difficulty in achieving or maintaining erections sufficient for sexual intercourse due to a true medical problem. It is not an aphrodisiac (sexual stimulant) and will not increase sexual desire. Unlike other treatments for erectile dysfunction, Viagra requires sexual stimulation to function. Without this stimulation, Viagra won’t have any effect.
Viagra works by blocking an enzyme found mainly in the penis that breaks down chemicals produced during sexual stimulation that normally produce erections. Viagra allows these chemicals of arousal to survive longer and improves erectile function. That is also why sexual stimulation is necessary for Viagra to work.
In general, Viagra works successfully in about 65-70% of all impotent men.
Viagra works best if taken about 30 to 60 minutes before sexual activity. Only 1 tablet should be taken per day. It should be taken on an empty stomach. Increasing the dosage of Viagra beyond the recommended amounts will not improve the response and will only result in greater side effects.
Several drugs very similar to Viagra have recently been approved by the FDA. These drugs, called vardenafil (Levitra), Stendra (avanafil) and tadalafil (Cialis), have essentially the same activity and general precautions as Viagra. Levitra may be taken with food where Viagra needs to be taken on an empty stomach. Cialis has a much longer duration of improved erection function (up to 24-36 hours) compared with Viagra and Levitra (up to 4 to 6 hours). Cialis in daily dosage now has FDA approval for treatment of patients with benign prostatic hyperplasia and erectile dysfunction for clinical situations where treatment of both conditions has been shown to be of medical necessity. Stendra is effective when taken with or without food, and it works within 15 minures. Moderate consumption of alcoholic beverages is possible with Stendra.
Do ED drugs have side effects?
The most common side effect of Viagra and similar drug use is headache, affecting about 16% of users. A drop in blood pressure, transient dizziness, and facial flushing (red face) are reported in 10%. Indigestion occurs in 7% and nasal congestion in 4%. Between 3% and 11% of users report some visual problems while on Viagra. This visual disturbance is described as either blurred vision, increased light sensitivity, persistence of a bluish tinge, or temporary loss of the ability to distinguish between blue and green.
Cautions: Viagra, Levitra, and Cialis are absolutely not to be taken by men with heart conditions who are taking nitrates such as nitroglycerine or isosorbide (Isordil, Ismo, Imdur). Certain street drugs such as “poppers” also can cause serious problems if taken with Viagra, Levitra, or Cialis. Ecstasy is a street drug that may increase sexual desire but interferes with performance. This has prompted some men to combine ecstasy with Viagra, Levitra, or Cialis. This mixture (a combination sometimes called “sextasy”) can improve erection ability but also causes severe headache and priapism. (Priapism is an abnormally prolonged erection that becomes extremely painful and may result in permanent damage to the erection mechanism.) There are also potentially dangerous effects to your heart from mixing Viagra and similar medications with various other street drugs.